A trigger for myelination

ome cells can induce the production of their own protective blanket. The signal comes from active neurons in the central nervous system (CNS), and triggers the differentiation of oligodendrocyte precursor cells (OPCs)—thus yielding the cells that cover the neurons with a protective sheath of myelin. Now, Beth Stevens, Douglas Fields, and colleagues (National Institutes of Health, Bethesda, MD) have shown that the neurons accomplish this task by releasing a simple metabolite, adenosine. The finding could be critical for possible stem cell treatments for the myelinating disease multiple sclerosis. " The problem [with stem cell treatments] is not getting the stem cells; the problem is getting the cells to differentiate at the right stage, " says Fields. Adenosine looks like a promising stop signal for OPCs. And, as a further enticement, Fields showed that a brief exposure to adenosine might be enough to set cells on the right path. Fields added a wide variety of biomolecules to OPCs and found that adenosine alone could reduce proliferation and induce everything from differentiation markers to a differentiated morphology and myelination. Adenosine receptor antagonists, meanwhile, prevented the changes in OPC proliferation and morphology normally caused by active neurons.